Bonno Nammen Bouma

Title: Bonno Nammen Bouma: Innovator in Protein S Research

Introduction

Bonno Nammen Bouma is a notable inventor based in Baarn, Netherlands. He has made significant contributions to the field of biochemistry, particularly in the study of protein S and its variants. With a total of two patents to his name, Bouma's work focuses on therapeutic applications of recombinant proteins.

Latest Patents

Bouma's latest patents include innovations related to protein S deletion variants that are deficient in C4b binding protein (C4BP) binding activity. The inventions describe various functional variants of recombinant protein S that do not significantly bind C4BP. These variants are directed at deletion mutants of protein S, which possess cofactor activity toward activated protein C (APC) while lacking at least two postulated C4BP binding domains. Specifically, these deletion mutants lack amino acid residues 401-457 and 583-635 of the corresponding mature wild type human protein S.

Career Highlights

Throughout his career, Bouma has worked with prestigious institutions, including Rijksuniversiteit Leiden. His research has contributed to advancements in therapeutic reagents, particularly in the context of blood coagulation and related disorders.

Collaborations

One of his notable collaborators is Rogier Maria Bertina, with whom he has worked on various research projects.

Conclusion

Bonno Nammen Bouma's innovative work in the field of protein S research has led to significant advancements in therapeutic applications. His contributions continue to impact the scientific community and enhance our understanding of protein interactions.