Bjoern Schwer

Title: Bjoern Schwer: Innovator in Mitochondrial Research

Introduction

Bjoern Schwer is a prominent inventor based in Brookline, MA (US). He has made significant contributions to the field of mitochondrial research, particularly in the regulation of protein activity through reversible acetylation. With a total of 2 patents, his work has implications for various metabolic conditions.

Latest Patents

One of Schwer's latest patents is focused on the regulation of protein activity by reversible acetylation. This invention reveals the first cellular acetylated substrate protein of SIRT3, known as Acetyl-CoA synthetase 2 (AceCS2). AceCS2 is a mitochondrial matrix protein that is reversibly acetylated at lysine 642 (Lys642) in the active site of the enzyme. The mitochondrial sirtuin SIRT3 interacts with AceCS2 and deacetylates Lys642 both in vitro and in vivo. The deacetylation of AceCS2 by SIRT3 activates its acetyl-CoA synthetase activity. This discovery indicates that a mammalian sirtuin directly controls the activity of a metabolic enzyme via reversible lysine acetylation. Modulators of the acetylation status or the activity of AceCS2 are useful for treating pathological conditions such as type II diabetes, hypercholesterolemia, hyperlipidemia, and obesity.

Another significant patent by Schwer provides methods for identifying agents that modulate the level or activity of a mitochondrial NAD-dependent deacetylase polypeptide. This invention also outlines methods for modulating mitochondrial function by influencing the activity of mitochondrial NAD-dependent deacetylase.

Career Highlights

Bjoern Schwer has worked at notable institutions, including the J. David Gladstone Institutes and the University of California. His research has been pivotal in advancing our understanding of mitochondrial functions and their implications for health.

Collaborations

Schwer has collaborated with esteemed colleagues such as Eric M Verdin and Brian J North, contributing to a rich exchange of ideas and innovations in his field.

Conclusion

Bjoern Schwer's innovative work in mitochondrial research and his patents highlight his significant contributions to science and medicine. His findings have the potential to impact the treatment of various metabolic disorders, showcasing the importance of his research in the field.