This inventor holds 1 USPTO granted patent. Top assignee: University of Southern California. Active years: 2016.
Company Filing History:
Years Active: 2016
Title: Innovation in DNA Methylation Analysis: The Contributions of Binh N Trinh
Introduction: Binh N Trinh is an accomplished inventor based in Alhambra, CA, whose work focuses on groundbreaking methods in DNA methylation analysis. With a notable patent under his name, Trinh has contributed significantly to the field of molecular diagnostics, paving the way for more sensitive cancer detection techniques.
Latest Patents: Trinh's patent, titled "DNA methylation analysis by digital bisulfite genomic sequencing and digital methylight," provides novel sensitive methylation assays referred to as Digital MethyLight. This innovative method involves stochastically distributing and compartmentalizing bisulfite-treated genomic DNA over multiple PCR reaction wells, allowing for the detection of individually methylated DNA molecules within a large background of unmethylated DNA. His techniques also offer high-resolution DNA methylation information without the need for subcloning, effectively diluting background signals and PCR contaminants while maintaining a high ratio of primer to methylated template DNA. Notably, biological fluid samples such as urine and blood (plasma or serum) are analyzed for cancer diagnosis, prognosis, and surveillance. The patent also includes multiplexed PCR formats to enhance the analysis when using small amounts of DNA.
Career Highlights: Binh N Trinh is affiliated with the University of Southern California, where he continues to advance research in the field of genomic sequencing and methylation analysis. His focused efforts contribute to the greater field of cancer diagnostics, specifically in using gene markers such as FOXE1, CLDN5, and RUNX3 for the diagnosis and prognosis of breast cancer.
Collaborations: Throughout his career, Trinh has collaborated with esteemed colleagues, including Peter W. Laird and Mihaela Campan. Their combined expertise contributes to innovative developments in DNA methylation and its applications in cancer research, reinforcing the importance of teamwork in scientific progress.
Conclusion: Binh N Trinh exemplifies the spirit of innovation in the rapidly evolving field of molecular biology. Through his patent and ongoing work at the University of Southern California, he continues to enhance our understanding of DNA methylation, ultimately leading to improved cancer diagnostic methods. His contributions in collaboration with notable colleagues further highlight the essence of teamwork in achieving breakthroughs in science.