Billie Gould

Title: Billie Gould and Cancer Detection Through Nucleic Acid Methylation Analysis.

Introduction

Billie Gould is an inventor associated with San Mateo, California, and Freenome Holdings, Inc. Her patent work concerns methods for detecting cancer and monitoring disease through analysis of nucleic acid methylation.

Latest Patents

Gould is named on 1 patent: “Methods and Systems for Detecting Cancer via Nucleic Acid Methylation Analysis.” The disclosed methods analyze cell-free nucleic acids, such as cell-free DNA, and identify methylation signals in sequencing reads from selected genomic regions. These signals can be used as features for training a machine-learning model that distinguishes groups, including healthy individuals and people with cancer, or differentiates disease subtypes and stages. Potential applications include predicting and monitoring treatment response, tumor burden, relapse, and cancer development.

Career Highlights

Gould’s listed patent reflects work at the intersection of genomic sequencing, methylation analysis, and machine learning. The approach described in the patent includes extracting DNA from a cell-free sample, preparing it for methylation sequencing, analyzing the resulting reads, and using detected signals to train a classifier.

Collaborations

Gould is associated with Freenome Holdings, Inc. Her listed coworkers include Shivani Mahajan and Peter Ulz.

Conclusion

Billie Gould’s patent focuses on using cell-free DNA methylation signals and machine learning to support cancer detection, disease classification, and monitoring.