Beth A Paape

Title: The Innovative Contributions of Beth A. Paape

Introduction

Beth A. Paape is a notable inventor based in San Pedro, California. She has made significant contributions to the field of peptide sequencing through her innovative methods. With one patent to her name, her work exemplifies the intersection of chemistry and biotechnology.

Latest Patents

Beth A. Paape's patent, titled "Method of thioacylation peptide sequencing with alcoholysis," presents a novel sequencing method that exploits the thioacylation degradation of polypeptides and proteins. This process involves the reaction of the N-terminal amino acid of a polypeptide with an excess of a thioacylating reagent. After allowing sufficient time for quantitative coupling and removing the excess reagent, the N-thioacyl polypeptide undergoes cleavage by acid, resulting in a 2-substituted-5(4H)-thiazolinone of the N-terminal amino acid. The subsequent addition of a large excess of an aliphatic primary or secondary alcohol yields the corresponding N-thioacyl amino acid ester, a stable compound suitable for chromatographic separation and detection by high-pressure liquid chromatography.

Career Highlights

Beth A. Paape is associated with Bio-Affinity Systems, Inc., where she continues to advance her research and development efforts. Her work has contributed to the understanding and application of peptide sequencing techniques, which are crucial in various biotechnological applications.

Collaborations

Throughout her career, Beth has collaborated with notable colleagues, including Mark L. Stolowitz and Anne E. DeVaux. These collaborations have fostered a productive environment for innovation and research.

Conclusion

Beth A. Paape's contributions to peptide sequencing through her patented methods highlight her role as an influential inventor in the field. Her work continues to impact the biotechnology sector positively.