Bernhard Noll

Title: Bernhard Noll: Innovator in RNA-Sequencing Technology

Introduction

Bernhard Noll is a prominent inventor based in Hilden, Germany. He has made significant contributions to the field of molecular biology, particularly in the area of RNA sequencing. His innovative methods have paved the way for advancements in understanding gene expression and regulation.

Latest Patents

Bernhard Noll holds a patent for a novel method for generating an RNA-sequencing library. This invention refers to a method of preparing strand-specific RNA-sequencing libraries that can be utilized to identify both DNA coding and non-coding strands that are transcribed to RNA. Such strand-specific RNA-sequencing libraries are especially beneficial in discovering anti-sense RNA and non-coding RNA. The method employs random primer oligonucleotides, covalently coupled to a moiety that blocks ligation, for the reverse transcription reaction or the subsequent generation of the second DNA strand. This ensures that only one strand of the generated double-stranded DNA is ligated to sequencing adapters at the 5' nucleotide and sequenced by paired-end sequencing. He has 1 patent to his name.

Career Highlights

Bernhard Noll is associated with Qiagen GmbH, a leading company in the field of molecular diagnostics and life sciences. His work at Qiagen has allowed him to contribute to cutting-edge research and development in RNA technologies.

Collaborations

Throughout his career, Bernhard has collaborated with notable colleagues, including Nan Fang and Katja Heitz. These collaborations have further enhanced the impact of his work in the scientific community.

Conclusion

Bernhard Noll's innovative approach to RNA-sequencing technology has made a significant impact in the field of molecular biology. His contributions continue to influence research and development in understanding gene expression.