Company Filing History:
22 out of 22 
5 out of 5 
2 out of 5 Years Active: 2016-2025
Title: Bernardus Nicolaas Machielse: Innovator in Pharmaceutical Sciences
Introduction
Bernardus Nicolaas Machielse is a prominent inventor based in North Potomac, MD, with an impressive portfolio of 24 patents. His work has significantly contributed to the field of pharmaceutical sciences, particularly through innovative compositions and methodologies.
Latest Patents
Among Machielse's latest inventions is his patent on hydroxypropyl beta-cyclodextrin compositions. This patent involves mixtures of beta-cyclodextrin molecules, where some hydroxyl positions are substituted with hydroxypropyl groups. These mixtures, which can also include unsubstituted beta-cyclodextrin molecules, are intended for use as pharmaceutically active ingredients. His innovative methods detail the production and qualification of these mixtures for pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration. Notably, his work aims to provide effective treatments for Niemann-Pick disease Type C, showcasing the applied therapeutic potential of his inventions.
Career Highlights
Machielse's impressive career includes significant contributions while working with companies such as Mandos LLC and Vtesse Inc. These organizations have been pivotal in furthering his research and development efforts within the pharmaceutical industry, reflecting his commitment to addressing complex medical challenges.
Collaborations
Throughout his career, Machielse has collaborated with notable professionals, including Allan Darling and Timothy J Maines. These partnerships highlight the importance of teamwork and collaboration in driving innovation and advancing pharmaceutical research.
Conclusion
Bernardus Nicolaas Machielse stands out as an influential inventor with a strong focus on pharmaceutical innovations. His dedication to developing novel compositions and methods serves to enhance treatment options, particularly in addressing rare diseases. With numerous patents to his name, Machielse continues to embody the spirit of discovery and innovation essential to the advancement of medicine.