Bernard Jacobson

Title: Innovations of Bernard Jacobson: A Pioneer in Cell Proliferation Inhibition

Introduction

Bernard Jacobson, an accomplished inventor based in Lexington, MA, has made significant contributions to the field of biomedical research. With a portfolio of three patents, Jacobson has focused on understanding cell growth mechanisms and developing methods to inhibit unnecessary cell proliferation.

Latest Patents

Jacobson's latest inventions include innovative techniques related to the isolation of high molecular weight aortic endothelial cell growth inhibitors. One notable patent describes the extraction of a cell proliferation inhibitor from liquified vitreous gel, which is prepared through a non-extractive technique. This gel has been found to contain a molecular-size inhibitor, exceeding 10,000 daltons, that effectively inhibits the growth of endothelial cells derived from calf aorta. Both bovine and chick embryo-derived vitreous have displayed this significant activity. Furthermore, culture medium conditioned by hyalocytes, which are cells from the peripheral region of the vitreous gel, serves as an additional source for this high molecular weight inhibitor. Jacobson also developed methods for isolating the inhibitor via chromatography and ultrafiltration, achieving active fractions both below and above a molecular weight of approximately 13,000 daltons.

Career Highlights

Throughout his career at the Boston Biomedical Research Institute, Jacobson has been dedicated to advancing research in cell biology and tissue engineering. His emphasis on non-extractive methods for isolating cell inhibitors highlights his innovative approach to addressing challenges in cell proliferation.

Collaborations

Jacobson has collaborated with his colleague, Laurie Raymond, enhancing the research capabilities within their institution. Their joint efforts exemplify the importance of teamwork in driving forward groundbreaking discoveries in the biomedical field.

Conclusion

Bernard Jacobson's ongoing innovations and patents reflect his commitment to advancing our understanding of cellular mechanisms. His work has tremendous implications in medical research and therapy, shedding light on methods to control cell growth in various contexts.