The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 1987
Filed:
Feb. 12, 1986
Applicant:
Inventor:
Bernard Jacobson, Lexington, MA (US);
Assignee:
Boston Biomedical Research Institute, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12P / ;
U.S. Cl.
CPC ...
435 68 ; 435212 ; 435219 ; 435226 ; 530350 ; 514-2 ;
Abstract
This invention comprises preparing a cell proliferation inhibitor by a nonextractive method from a tissue which has neither a high content of collagen, nor proteoglycans. The source of inhibitor comprises hyalocyte cells, which release the inhibitor into culture medium. The inhibitor is isolated from the culture medium. By chromatographic separation fractions are provided of varying molecular weight. Fractions both below and above a molecular weight of about 13,000 daltons show inhibitory activity.