Company Filing History:
3 out of 1,047 
2 out of 1,521 
2 out of 1,012 Years Active: 1991-2003
Title: Innovations by Basil Rigas
Introduction
Basil Rigas is a notable inventor based in White Plains, NY (US). He has made significant contributions to the field of cellular diagnostics, holding a total of 6 patents. His work focuses on innovative methods for detecting cellular abnormalities, particularly in relation to disease states.
Latest Patents
One of his latest patents is titled "Method for the detection of cellular abnormalities using Fourier transform infrared spectroscopy." This invention teaches a method to identify cellular abnormalities associated with disease states. The method utilizes infrared (IR) spectra of cell samples that are dried on an infrared-transparent matrix and scanned at a frequency range from 3000-950 cm-1. The identification of samples is based on establishing a reference using a representative set of spectra of normal and/or diseased specimens. During the reference assembly process, multivariate techniques such as Principal Component Analysis (PCA) and/or Partial Least Squares (PLS) are employed. PCA and PLS reduce the data based on maximum variations between the spectra and generate clusters in a multidimensional space representing different populations. The utilization of Mahalanobis distances or linear regression, such as Principal Component Regression on the reduced data from PCA, forms the basis for discrimination. In one embodiment, the invention distinguishes premalignant and malignant stages of cervical cancer from normal cervical cells. This method is simple to use and achieves statistically reliable distinctions between groups of cervical smears: normal, dysplasia, and malignant samples. Furthermore, this invention discloses a method to obtain the IR spectrum of individual cervical cells fixed on an infrared-transparent matrix and to use the spectra of the individual cells in the described method. Another aspect of the invention involves using vibrational spectroscopic imaging to distinguish between normal and diseased cells, as well as identifying women at high risk for developing cervical dysplasia.
Career Highlights
Basil Rigas has worked with prominent companies such as Bio-Rad Laboratories, Inc. and Cornell Research Foundation Inc. His experience in these organizations has contributed to his expertise in the field of cellular diagnostics.
Collaborations
Some of his notable coworkers include Menashi A Cohenford and Prashant S Bhandare. Their collaboration has likely enhanced the innovative processes and research outcomes in which Rigas has been involved.
Conclusion
Basil Rigas is a distinguished inventor whose work