Company Filing History:
Years Active: 2024
Title: Innovations in Genome Manipulation by Basil Hubbard
Introduction
Basil Hubbard is an accomplished inventor based in Cambridge, MA (US). He has made significant contributions to the field of genome manipulation, particularly through his innovative work on engineered transcriptional activator-like effectors (TALEs). His research focuses on enhancing the specificity and efficacy of these tools for various applications in both research and clinical settings.
Latest Patents
Hubbard holds a patent for the "Evolution of TALENs," which addresses some of the limitations associated with traditional TALEs. One notable drawback of TALEs is their specificity for the 5′ nucleotide thymine (T), which restricts the range of DNA target sequences they can bind. His patent outlines methods for evolving TALE domains to include alternative 5′ nucleotide specificities, thereby expanding their potential applications. Additionally, the patent discusses strategies for minimizing off-target binding, which is crucial for clinical applications that require high fidelity. The disclosure includes engineered TALE domains and TALEs, such as TALE nucleases (TALENs) and TALE transcriptional activators, with improved specificity for target sequences.
Career Highlights
Hubbard's work at Harvard College has positioned him as a leading figure in the field of genetic engineering. His innovative approaches to TALE technology have garnered attention and recognition within the scientific community. With a focus on continuous evolution of DNA-binding proteins, he has contributed to advancing the capabilities of genome editing tools.
Collaborations
Hubbard has collaborated with notable researchers, including David R Liu and Ahmed Hussein Badran. These partnerships have further enriched his research and expanded the impact of his innovations in genome manipulation.
Conclusion
Basil Hubbard's contributions to the field of genome manipulation through his patent on TALE technology exemplify the potential for innovation in genetic engineering. His work not only addresses existing challenges but also paves the way for future advancements in the field.