Bart Vanhasebroeck

Title: Bart Vanhasebroeck: Innovator in Cancer Research

Introduction

Bart Vanhasebroeck is a prominent inventor based in London, GB. He has made significant contributions to the field of cancer research, particularly through his work on lipid kinases. With a total of 2 patents, Vanhasebroeck's innovations are paving the way for advancements in cancer treatment.

Latest Patents

Vanhasebroeck's latest patents include a method for determining modulation of p110δ activity. This invention relates to a novel lipid kinase that is part of the PI3 Kinase family. PI3 Kinases are crucial as they catalyze the addition of phosphate to inositol, generating inositol mono, di, and triphosphate. Inositol phosphates play a vital role in regulating intracellular signaling cascades, which can lead to alterations in gene expression. These changes can result in cytoskeletal remodeling and modulation of cellular motility. More specifically, the invention focuses on a novel human PI3 Kinase, p110δ, which interacts with p85 and has a broad phosphoinositide specificity. It is sensitive to the same kinase inhibitors as PI3 Kinase p110A. Unlike previously identified PI3 Kinases that exhibit a ubiquitous expression pattern, p110δ is selectively expressed in leukocytes. Notably, p110δ shows enhanced expression in most melanomas tested, suggesting it may play a crucial role in regulating the metastatic properties of melanomas. Identifying agents that can enhance or reduce p110δ activity could potentially prevent cancer metastasis.

Career Highlights

Vanhasebroeck is associated with the Ludwig Institute for Cancer Research Limited, where he continues to explore innovative solutions in cancer research. His work is characterized by a commitment to understanding the molecular mechanisms underlying cancer progression.

Collaborations

Vanhasebroeck collaborates with notable colleagues in the field, including Michael Derek Waterfield. Their combined expertise contributes to the advancement of cancer research and the development of new therapeutic strategies.

Conclusion

Bart Vanhasebroeck is a key figure in the realm of cancer research, with his innovative patents and collaborations driving forward the understanding of cancer biology. His work holds promise for future advancements in cancer treatment and prevention.