Company Filing History:
Years Active: 2020-2024
Title: Barry Ticho: Innovator in mRNA Therapy
Introduction
Barry Ticho is a prominent inventor based in Newton, MA (US). He has made significant contributions to the field of mRNA therapy, particularly in the treatment of fibrosis and cardiovascular diseases. With a total of 2 patents, Ticho's work is paving the way for innovative therapeutic approaches.
Latest Patents
Ticho's latest patents focus on polynucleotides encoding relaxin. The invention relates to mRNA therapy designed to treat fibrosis and/or cardiovascular disease. The mRNAs developed for this invention, when administered in vivo, encode human relaxin, its isoforms, functional fragments, and fusion proteins. These mRNAs are preferably encapsulated in lipid nanoparticles (LNPs) to ensure efficient delivery to cells and tissues in subjects. The mRNA therapies aim to increase and restore deficient levels of relaxin expression and activity, while also decreasing levels of toxic metabolites associated with deficient relaxin activity.
Career Highlights
Barry Ticho is currently associated with Modernatx, Inc., where he continues to advance his research and innovations in mRNA therapies. His work is crucial in addressing significant health challenges related to fibrosis and cardiovascular diseases.
Collaborations
Ticho collaborates with notable colleagues, including Nadege Briancon-Eris and Zhinan Xia, who contribute to the research and development of mRNA therapies.
Conclusion
Barry Ticho's innovative work in mRNA therapy represents a significant advancement in medical science. His contributions are essential for developing effective treatments for serious health conditions.