Location History:
- Bloomingdale, NJ (US) (1987)
- Wayne, PA (US) (1998)
- West Milford, NJ (US) (2001)
Company Filing History:
Years Active: 1987-2001
Title: The Innovations of Barry N. Jones
Introduction
Barry N. Jones is a notable inventor based in West Milford, NJ (US). He has made significant contributions to the field of enzymatic compositions, holding a total of three patents. His work focuses on the development of alpha-amidating enzymes, which play a crucial role in the production of biologically important compounds.
Latest Patents
One of his latest patents is titled "Alpha-amidating enzyme compositions and processes for their production and use." This patent describes purified enzymatic compositions that contain alpha-amidating enzymes capable of converting peptidyl compounds with a C-terminal glycine residue into corresponding peptidyl amides. The purified compositions exhibit specific activities exceeding 25 mU per mg of protein and are designed to be free of proteases, allowing for effective catalysis of peptidyl compounds with L-amino acids. The alpha-amidation reaction catalyzed by these enzymes efficiently produces biologically significant products, such as calcitonin and other regulatory hormones. The purification process involves size exclusion chromatography combined with strong anion exchange chromatography, resulting in homogeneous enzyme species that can be used to prepare antibodies specific for the alpha-amidating enzyme. Additionally, he has developed expression systems for the amidating enzyme, utilizing recombinant DNA techniques to achieve high yields and purity.
Career Highlights
Barry N. Jones is currently associated with Unigene Laboratories Inc., where he continues to innovate in the field of enzymatic research. His work has contributed to advancements in the production of important biological compounds, showcasing his expertise and dedication to the field.
Collaborations
Throughout his career, Barry has collaborated with notable colleagues, including James P. Gilligan and Arthur H. Bertelsen. These collaborations have further enhanced his research and development efforts in enzymatic compositions.
Conclusion
Barry N. Jones is a distinguished inventor whose work in alpha-amidating enzymes has significant implications for the production of biologically important compounds. His contributions to the field are marked by his innovative patents and collaborations with esteemed colleagues.