Company Filing History:
Years Active: 1990-1993
Title: **Innovations by Barbara J. Weigel: Pioneering Advances in Biotechnology**
Introduction
Barbara J. Weigel is a distinguished inventor based in Indianapolis, Indiana. She has made significant contributions to the field of biotechnology, earning a commendable number of patents that showcase her innovative spirit and dedication to advancing medical science.
Latest Patents
Weigel holds three patents, with her latest inventions focusing on novel tissue plasminogen activator derivatives. One notable invention discloses modified forms of the enzyme tissue plasminogen activator (t-PA) using recombinant DNA techniques. This invention retains the enzyme's ability to activate plasminogen while improving its interaction with plasmin inhibitors. Weigel's work includes the creation of novel DNA compounds and recombinant DNA expression vectors that encode modified human t-PA with altered kringle protein domains. These modifications have been successfully tested in both eukaryotic and prokaryotic systems.
Another significant patent of hers involves the development of recombinant DNA compounds focused on monoclonal antibody KS1/4 and its chimeric derivatives. By constructing eukaryotic expression vectors, Weigel's inventions enable the expression of KS1/4 when transformed into an appropriate host cell. The resulting recombinant KS1/4 and its derivatives hold promise for diagnosing, prognosing, and treating various disease states, including adenocarcinoma.
Career Highlights
Barbara J. Weigel has made her mark in the industry as a talented inventor at Eli Lilly and Company. Her commitment to biotechnology and innovative research has driven her career, leading to breakthroughs that impact modern medicine and treatment options.
Collaborations
Throughout her career, Weigel has collaborated with esteemed colleagues, including Lisa Selsam Beavers and Thomas F. Bumol. These partnerships highlight the collaborative spirit within the scientific community and reinforce the importance of teamwork in achieving significant advancements in biotechnology.
Conclusion
Barbara J. Weigel's contributions to the field of biotechnology through her innovative inventions are a testament to her expertise and dedication. With her substantial number of patents and impactful collaborations, she continues to play a vital role in the development of advanced medical therapies, paving the way for future discoveries in the realm of health and wellness.