Barbara A Centeno

Title: The Innovative Contributions of Barbara A. Centeno

Introduction

Barbara A. Centeno is a prominent inventor based in Tampa, Florida, known for her significant contributions to the field of pathology. She has developed a unique hybrid model for the classification of carcinoma subtypes, which has the potential to enhance the accuracy of cancer diagnosis.

Latest Patents

Centeno holds a patent for her invention titled "Hybrid model for the classification of carcinoma subtypes." This two-tiered classification system can be integrated with existing algorithms used by pathologists to identify the site of origin for malignancies with unknown primary. The model utilizes morphology, immunohistochemical studies, and microarray-based top-tier gene expression classifiers to subclassify cytokeratin positive carcinomas into various types, including adenocarcinoma, squamous cell carcinoma, neuroendocrine carcinoma, and urothelial carcinoma. The second tier employs organ-specific IHC markers and additional gene expression classifiers to determine the primary site of origin, thereby assisting pathologists in refining their decision-making processes.

Career Highlights

Barbara A. Centeno is affiliated with the H. Lee Moffitt Cancer Center and Research Institute, Inc., where she continues to advance her research in cancer classification and diagnosis. Her work is instrumental in bridging the gap between traditional pathology and modern molecular techniques.

Collaborations

Throughout her career, Centeno has collaborated with notable colleagues, including Timothy J. Yeatman and Gregory C. Bloom. These partnerships have further enriched her research and contributed to the development of innovative diagnostic tools in oncology.

Conclusion

Barbara A. Centeno's innovative approach to carcinoma classification exemplifies the intersection of technology and medicine. Her contributions are paving the way for improved diagnostic accuracy in cancer pathology, ultimately benefiting patient care.