Location History:
- Raleigh, NC (US) (2000)
- Lexington, KY (US) (2011 - 2015)
- Neuchatel, CH (2012 - 2023)
Company Filing History:
14 out of 1,440 
13 out of 882 
1 out of 1,300 
Years Active: 2000-2023
Title: **Balazs Siminszky: Innovator in Tobacco Genetic Modification**
Introduction
Balazs Siminszky, an accomplished inventor based in Neuchatel, Switzerland, has made significant strides in the field of genetic engineering, particularly concerning tobacco. With a remarkable portfolio of 15 patents, his contributions focus on altering tobacco alkaloid content to reduce harmful substances in tobacco products.
Latest Patents
Among his latest patents, Balazs has developed novel compositions and methods aimed at reducing the levels of nornicotine and N'-nitrosonornicotine (NNN) in plants. These innovations involve isolated polynucleotides and polypeptides for cytochrome P450 enzymes that play a crucial role in the metabolic conversion of nicotine to nornicotine. His patents detail expression cassettes and vectors that carry inhibitory sequences targeting the expression or function of these cytochrome P450 polypeptides. The methods outlined within these patents hold promising applications for producing tobacco products that exhibit lower levels of nornicotine and its carcinogenic metabolite, NNN, thereby lessening the carcinogenic potential for consumers and those exposed to secondary smoke.
Career Highlights
Balazs Siminszky has garnered extensive experience through his tenure at esteemed research institutions. He has contributed to advancements at North Carolina State University and the University of Kentucky Research Foundation. His work reflects an ongoing commitment to improving public health through scientific research and innovation.
Collaborations
Throughout his career, Balazs has collaborated with notable colleagues in the field, including Ralph E. Dewey and Steven W. Bowen. These collaborations have further enriched his research, drawing from a diversity of expertise that enhances the impact of his work.
Conclusion
Balazs Siminszky stands out as a pioneer in the genetic modification of tobacco plants with the objective of reducing harmful substances. His innovative patents and dedicated collaborations demonstrate his commitment to advancing healthier tobacco products, contributing to public health initiatives, and influencing future research in the field.