Baisong Lu

Title: Baisong Lu: Innovator in Gene Editing Technologies

Introduction

Baisong Lu is a prominent inventor based in Winston Salem, NC (US). He has made significant contributions to the field of gene editing, particularly through his innovative patents. With a total of 2 patents, Lu's work focuses on advancing the capabilities of eukaryotic gene editing.

Latest Patents

Lu's latest patents include "Lentiviral-based vectors and related systems and methods for eukaryotic gene editing." This invention provides compositions, systems, and methods useful for effecting gene editing in eukaryotic cells. The compositions include plasmids that encode one or more viral fusion proteins, which are fused with an aptamer-binding protein. Additionally, the plasmids can encode a non-viral nucleic acid sequence that includes a CRISPR system component. These plasmids can be utilized to generate viral particles, including lentivirus-like particles that contain both a viral fusion protein and a non-viral RNA sequence. The methods outlined in this patent enable the use of these viral particles for gene editing in eukaryotic cells.

Another notable patent is the "Non-viral episomal suicide construct." This invention encompasses compositions and methods for the selective expression of a target gene in a subset of cells. The construct comprises a first nucleic acid sequence with an episomal maintenance element and a second nucleic acid sequence that includes a target gene. The expression of the episomal maintenance element is regulated by a constitutive promoter, while the target gene's expression is controlled by a non-constitutive promoter. This construct is designed to maintain an episomal state, regardless of whether the target gene is expressed in the cell.

Career Highlights

Baisong Lu is affiliated with Wake Forest University, where he continues to push the boundaries of gene editing technology. His work has garnered attention for its potential applications in various fields, including medicine and biotechnology.

Collaborations

Lu collaborates with esteemed colleagues such as Anthony Atala and Qingguo Zhao, further enhancing the impact of his research and innovations.

Conclusion

Baisong Lu's contributions to gene editing through his innovative patents demonstrate his commitment to advancing scientific knowledge and technology. His work at Wake Forest University positions him as a key figure in the ongoing evolution of gene editing methodologies.