Location History:
- Neunkirchen, TR (2001)
- Lexington, KY (US) (2005)
Company Filing History:
Years Active: 2001-2005
Title: Ayhan S Demir: Innovator in Oligonucleotide Delivery Systems
Introduction
Ayhan S Demir is a prominent inventor based in Lexington, KY (US). He has made significant contributions to the field of drug delivery systems, particularly focusing on camptothecin drugs. With a total of 2 patents, his work has the potential to enhance cancer treatment methodologies.
Latest Patents
Demir's latest patents include innovative approaches to drug delivery. One of his notable inventions is the "Oligonucleotide delivery systems for camptothecins." This patent describes how camptothecin drugs can be stabilized in their antitumor active lactone form through complexation with an oligonucleotide, which may include RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex can be incorporated within a macromolecular assembly, utilizing both viral and non-viral oligonucleotide vectors. This invention allows for a combination of gene therapy and camptothecin drug therapy, potentially improving treatment outcomes for cancer patients.
Another significant patent is for "Water-soluble derivatives of camptothecin/homocamptothecin." This invention provides camptothecin and homocamptothecin analogs and derivatives that incorporate alkylamine and polyalkylamine moieties, enhancing their solubility and effectiveness.
Career Highlights
Ayhan S Demir is affiliated with the University of Kentucky Research Foundation, where he conducts his research and development activities. His work is characterized by a strong focus on innovative drug delivery systems that aim to improve therapeutic efficacy.
Collaborations
Demir has collaborated with notable colleagues such as Thomas G Burke and Ashok J Chavan, contributing to the advancement of research in his field.
Conclusion
Ayhan S Demir's contributions to the field of drug delivery systems, particularly through his patents on camptothecin drugs, highlight his role as an innovator in the medical research community. His work continues to pave the way for advancements in cancer therapy.