The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2005
Filed:
Oct. 14, 1998
Applicants:
Thomas G. Burke, Lexington, KY (US);
Ayhan S. Demir, Lexington, KY (US);
Ashok J. Chavan, Lexington, KY (US);
Danzhou Yang, Lexington, KY (US);
Inventors:
Thomas G. Burke, Lexington, KY (US);
Ayhan S. Demir, Lexington, KY (US);
Ashok J. Chavan, Lexington, KY (US);
Danzhou Yang, Lexington, KY (US);
Assignee:
University of Kentucky Research Foundation, Lexington, KY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K048/00 ; C07D491/22 ;
U.S. Cl.
CPC ...
Abstract
Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.