Location History:
- Santiago, CL (2002)
- Malden, MA (US) (1999 - 2005)
Company Filing History:
3 out of 8,370 
2 out of 2,596 
2 out of 5,445 
Years Active: 1999-2005
Title: The Innovative Contributions of Attilio Rigotti
Introduction
Attilio Rigotti is a notable inventor based in Malden, MA (US), recognized for his significant contributions to the field of cholesterol transport and metabolism. With a total of 4 patents, Rigotti's work has advanced our understanding of lipid regulation and its implications for health.
Latest Patents
Rigotti's latest patents focus on methods for modulation of cholesterol transport. These methods describe the regulation of lipid and cholesterol uptake through the expression or function of the SR-BI HDL receptor. His research demonstrates that estrogen dramatically downregulates SR-BI under conditions of significant upregulation of the LDL-receptor. Additionally, his findings reveal the upregulation of SR-BI in rat adrenal membranes and other non-placental steroidogenic tissues treated with estrogen, while not affecting other non-placental non-steroidogenic tissues such as the lung, liver, and skin. Furthermore, his work illustrates the uptake of fluorescently labeled HDL into liver cells, which is inhibited when animals are treated with estrogen. Rigotti's research also highlights the in vivo effects of SR-BI expression on HDL metabolism, particularly in mice that transiently overexpress hepatic SR-BI following recombinant adenovirus infection. This overexpression leads to a dramatic decrease in cholesterol blood levels, indicating that modulation of SR-BI levels can effectively influence cholesterol levels in the blood.
Career Highlights
Throughout his career, Attilio Rigotti has worked with prestigious institutions such as the Massachusetts Institute of Technology and the University of Pennsylvania. His research has not only contributed to academic knowledge but has also paved the way for potential therapeutic applications in cholesterol management.
Collaborations
Rigotti has collaborated with esteemed colleagues, including Monty Krieger and Karen Kozarsky, further enhancing the impact of his research through shared expertise and innovative ideas.
Conclusion
Attilio Rigotti's innovative work in cholesterol transport and metabolism has made significant strides in understanding lipid regulation. His patents and research findings continue to influence the field and hold promise for future advancements in health and medicine.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.