Company Filing History:
Years Active: 2008
Title: Innovations of Ashlesh Sheth in Pharmaceutical Dosage Forms
Introduction
Ashlesh Sheth is a notable inventor based in Randolph, NJ, who has made significant contributions to the field of pharmaceuticals. He is recognized for his innovative approach to oral peptide delivery systems, which enhance the bioavailability of therapeutic peptides.
Latest Patents
One of Ashlesh Sheth's key patents is titled "Oral peptide pharmaceutical dosage form and method of production." This patent describes a pharmaceutical composition designed for oral delivery of a peptide, structured as a lamination with at least two layers. The first layer contains a pharmaceutically acceptable pH-lowering agent, while the second layer includes a therapeutically effective amount of the peptide. Additionally, the composition incorporates an absorption enhancer to promote the peptide's bioavailability, preferably located in the second layer, and is surrounded by an enteric coating. A water-soluble coating is also applied between the lamination and enteric coating to prevent contact between the pH-lowering agent and the enteric coating. In a preferred embodiment, the peptide is salmon calcitonin, the pH-lowering agent is citric acid, and the absorption enhancer is lauroyl l-carnitine.
Career Highlights
Ashlesh Sheth is currently associated with Unigene Laboratories Inc., where he continues to develop innovative pharmaceutical solutions. His work focuses on improving the delivery mechanisms of peptide-based medications, which are crucial for various therapeutic applications.
Collaborations
Throughout his career, Ashlesh has collaborated with notable colleagues, including George Crotts and Isaac Ghebre-Sellassie. These collaborations have contributed to the advancement of research and development in the pharmaceutical industry.
Conclusion
Ashlesh Sheth's contributions to the field of pharmaceuticals, particularly in oral peptide delivery systems, highlight his innovative spirit and dedication to improving patient outcomes. His work continues to influence the development of effective therapeutic solutions.