Asher Ameli

Title: Asher Ameli and Network Medicine for Drug Repurposing

Introduction

Asher Ameli is an inventor based in Kenmore, Washington. His work includes a patented network medicine framework designed to identify potential drug-repurposing opportunities for diseases caused by pathogens.

Latest Patents

Ameli is associated with 1 patent, titled “Network Medicine Framework for Identifying Drug Repurposing Opportunities.” The patent describes methods and systems that combine a protein-protein interaction network, a graph neural network, diffusion and proximity modules, and an aggregation module to predict candidate drugs for treating a disease.

The graph neural network predicts potential connections between candidate-drug nodes and disease nodes in an embedded representation of the interaction network. Other modules assess distances between relevant protein nodes, including pathogen-protein and drug-protein pairs. The aggregation module uses the candidate lists produced by these components to generate a ranked list of drugs predicted to be effective against the disease.

Career Highlights

Ameli’s listed professional affiliations include Northeastern University and Scipher Medicine Corporation. His patent reflects an application of computational network methods to drug discovery and repurposing.

Collaborations

His listed collaborators include Deisy Morselli Gysi and Albert-László Barabási. Their names are associated with the collaborative research context surrounding this work.

Conclusion

Asher Ameli’s patent presents a computational framework for ranking potential treatments by combining network analysis and machine-learning methods, illustrating how these tools can support drug-repurposing research.