Arumugavadivel Narendran

Title: Arumugavadivel Narendran and a Small-Molecule Approach to Cancer Treatment.

Introduction

Arumugavadivel Narendran is an inventor associated with Calgary, Canada. His patent work addresses LIN28, an RNA-binding protein that can inhibit the expression and maturation of let-7 microRNA, which has important tumor-suppressor functions.

Latest Patents

Narendran is associated with 1 patent, titled “Small Molecule LIN28 Inhibitors as Anticancer Agents.” The disclosure describes the rationale, design, synthesis, and validation of a novel small-molecule LIN28 inhibitor, identified as a compound of formula (I), for potential use against adult and pediatric malignancies. It also discusses possible applications in blocking cancer metastasis, inhibiting cancer stem cells to help prevent relapse, and combining the agent with immunotherapy, chemotherapy, or radiotherapy.

Career Highlights

The available information identifies Narendran’s patent contribution but does not specify his employer or provide further details about his professional career.

Collaborations

Mohit Jain is identified as Narendran’s coworker. The supplied information does not describe their specific roles or contributions to the patent.

Conclusion

Arumugavadivel Narendran’s patent focuses on targeting LIN28 with a small molecule and outlines potential applications in cancer treatment, metastasis prevention, and combination therapies.