Arthur I Skoultchi

Title: Arthur I Skoultchi: Innovator in Gene Manipulation

Introduction

Arthur I Skoultchi is a prominent inventor based in Larchmont, NY (US), known for his significant contributions to the field of gene manipulation. With a total of three patents to his name, he has made remarkable advancements in the expression of mammalian target genes.

Latest Patents

Skoultchi's latest patents focus on innovative methods for gene manipulation and expression using genomic elements. One of his notable inventions involves the expression of mammalian target genes through the use of chromosomal target DNA, which can be derived from either native primary cells or yeast artificial chromosomes (YACs). This process allows for the integration of an amplifiable gene into a mammalian fragment, facilitating amplification and modification of the target gene through in vivo mutagenesis. The resulting constructs can be transformed into mammalian expression hosts, leading to high yields of desired proteins. Another patent outlines methods for expressing mammalian genes in culture, where an amplifiable gene is introduced by homologous recombination, enhancing the expression of the target gene in a convenient host.

Career Highlights

Arthur I Skoultchi has made significant strides in his career, particularly through his work at Cell Genesys, Inc. His innovative approaches to gene manipulation have positioned him as a key figure in the biotechnology industry.

Collaborations

Throughout his career, Skoultchi has collaborated with notable colleagues, including Stephen A Sherwin and Sue Klapholz. These partnerships have contributed to the advancement of research and development in gene expression technologies.

Conclusion

Arthur I Skoultchi's work in gene manipulation has paved the way for new methodologies in biotechnology. His patents reflect a deep understanding of genetic engineering, making him a valuable contributor to the field.