This inventor holds 4 USPTO granted patents. Top assignee: Duphar International Research Bv. Active years: 1993-1996.
Company Filing History:
Years Active: 1993-1996
Title: Arne Van Der Gen: Innovator in Cyanohydrin Derivatives
Introduction
Arne Van Der Gen is a notable inventor based in Weesp, Netherlands. He has made significant contributions to the field of chemistry, particularly in the preparation of optically active compounds. With a total of 4 patents to his name, Van Der Gen continues to push the boundaries of innovation in his area of expertise.
Latest Patents
One of his latest patents is a method of preparing optically active cyanohydrin derivatives. This invention involves converting an optically active cyanohydrin of opposite configuration with a carboxylic acid in the presence of a dialkyl azodicarboxylate and a triarylphosphine. The process also includes a method for preparing an optically active cyanohydrin of opposite configuration through solvolysis of the ester obtained while conserving the configuration.
Another significant patent focuses on the preparation of vicinal aminoalcohols. This invention details the process of obtaining N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives. The method includes successive partial reduction, transimination using a primary amine, and reduction of the resulting imine, with the option to remove the hydroxyl-protecting group. The products can be achieved either as a racemate or in an optically pure form, depending on the stereochemical composition of the starting materials.
Career Highlights
Arne Van Der Gen is currently associated with Duphar International Research Bv, where he applies his expertise in chemical research and development. His work has led to advancements in the synthesis of complex organic compounds, contributing to various applications in the pharmaceutical industry.
Collaborations
Throughout his career, Van Der Gen has collaborated with esteemed colleagues such as Johannes Brussee and Chris G Kruse. These partnerships have fostered a collaborative environment that enhances innovation and research outcomes.
Conclusion
Arne Van Der Gen is a distinguished inventor whose work in the field of cyanohydrin derivatives has led to valuable patents and advancements in chemistry. His contributions continue to impact the industry positively, showcasing the importance of innovation in scientific research.