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Years Active: 2012-2014
Title: Arnaud Gautier: Innovator in Protein Labelling Technologies
Introduction
Arnaud Gautier is a prominent inventor based in Lausanne, Switzerland. He has made significant contributions to the field of protein labelling, particularly through his innovative work on alkylcytosine transferases (ACTs). With a total of 2 patents, Gautier's inventions are paving the way for advancements in biochemical research.
Latest Patents
Gautier's latest patents focus on the labelling of fusion proteins with synthetic probes. His invention introduces new proteins known as alkylcytosine transferases (ACTs), which are derived from O-alkylguanine-DNA alkyltransferase. The patents detail substrates for ACTs that specifically transfer a label to these proteins and their fusion counterparts. The substrates are substituted cytosines of a specific formula, where R represents an aromatic or heteroaromatic group, or an optionally substituted unsaturated alkyl, cycloalkyl, or heterocyclyl group. The invention also outlines methods for transferring labels from these substrates to ACTs and ACT fusion proteins. This system is particularly advantageous for double labelling studies in conjunction with the established O-alkylguanine-DNA alkyltransferase (AGT)-benzylguanines system.
Career Highlights
Throughout his career, Gautier has worked with esteemed institutions such as École Polytechnique Fédérale de Lausanne and New England Biolabs, Inc. His experience in these organizations has allowed him to refine his expertise in protein chemistry and labelling techniques.
Collaborations
Gautier has collaborated with notable colleagues, including Kai Peter Johnsson and Maik Kindermann. These partnerships have contributed to the advancement of his research and the successful development of his patented technologies.
Conclusion
Arnaud Gautier's innovative work in the field of protein labelling has established him as a key figure in biochemical research. His contributions through patents and collaborations continue to influence the scientific community.