This inventor holds 1 USPTO granted patent. Top assignee: University of Virginia Patent Foundation. Active years: 2017.
Company Filing History:
Years Active: 2017
Title: Anusuya Das: Innovator in Tissue Engineering
Introduction
Anusuya Das is a prominent inventor based in Charlottesville, VA (US). He has made significant contributions to the field of tissue engineering and cell-based therapies. His innovative work focuses on strategies to enhance stem cell mobilization and recruitment, which has important implications for regenerative medicine.
Latest Patents
Anusuya Das holds a patent titled "Compositions and methods for tissue engineering and cell based therapies." This patent discloses strategies to recruit and mobilize stem cells using S1P receptor selective agonists and antagonists, as well as regulators of chemokine receptors. In an in vivo ischemic model, S1P/S1P activation with FTY720 impeded inflammatory cell infiltration and recruited endothelial progenitor cells (EPCs), which have the potential to increase microvascular remodeling. The expression of S1P on marrow-derived cells was essential for this remodeling. Concurrent systemic S1P and CXCR4 antagonism mobilized hematopoietic stem cells (HSCs) capable of engrafting and repopulating blood cells. Pre-treatment of donor HSCs with FTY720 increased their homing toward SDF-1 and improved engraftment in marrow. FTY720-coated bone allografts, coupled with systemic administration of VPC01091, enhanced bone allograft integration and new bone formation in bone defects. The results demonstrate that S1P plays a powerful role in pharmacological marrow-derived stem cell mobilization and recruitment.
Career Highlights
Anusuya Das is affiliated with the University of Virginia Patent Foundation, where he continues to advance research in tissue engineering. His work has garnered attention for its potential to revolutionize treatments in regenerative medicine.
Collaborations
Anusuya has collaborated with notable colleagues, including Edward A Botchwey, III and Mary J Laughlin, who contribute to the research and development of innovative therapies.
Conclusion
Anusuya Das is a key figure in the field of tissue engineering, with a focus on stem cell mobilization and recruitment. His contributions through patents and collaborations highlight the importance of innovation in advancing medical science.