Company Filing History:
Years Active: 2019-2025
Title: **Inventor Antonio Wolff: Pioneering Advancements in Breast Cancer Research**
Introduction
Antonio Wolff, an accomplished inventor based in Baltimore, MD, has made significant contributions to the field of cancer research. With two patents to his name, his work centers around innovative methodologies for detecting and analyzing tumor DNA, particularly in relation to breast cancer.
Latest Patents
Wolff's latest patents include a method known as the Quantitative Multiplex Methylation Specific PCR method (cMethDNA). This groundbreaking technique allows for the quantitative detection of tumor DNA in bodily fluids such as serum or plasma at unprecedented low copy numbers. Unlike existing PCR-based assays, the cMethDNA method incorporates a synthetic polynucleotide standard that is co-amplified with target genes, leading to improved accuracy in quantifying gene presence.
Another recent patent focuses on genome-wide methylation analysis, aimed at identifying gene markers that are specific to hormone receptor statuses in breast cancer. This research analyzed 103 primary invasive breast cancers against 21 normal breast samples, utilizing the Illumina Infinium HumanMethylation27 array to query thousands of CpG loci. Wolff's work has identified 40 unique CpG loci that show differential methylation patterns, offering potential biomarkers for disease progression and patient treatment strategies.
Career Highlights
Antonio Wolff works at The Johns Hopkins University, a prestigious institution renowned for its research and academic excellence. His position allows him to be at the forefront of innovative cancer research, contributing to advancements that may impact thousands affected by breast cancer.
Collaborations
In his research journey, Wolff collaborates with esteemed colleagues including Saraswati Vaidyanathan Sukumar and Mary Jo Fackler. Together, they aim to enhance the understanding of breast cancer biology and improve diagnostic methods through coordinated research efforts.
Conclusion
Antonio Wolff stands out as a significant inventor in the realm of cancer research. His pioneering patents and collaborative efforts at The Johns Hopkins University are paving the way for new strategies to better understand and treat breast cancer, ultimately contributing to advancements in patient care and outcomes.