Company Filing History:
Years Active: 2003
Title: Antonio Giachetti: Innovator in Pharmaceutical Chemistry
Introduction
Antonio Giachetti is a notable inventor based in Pomezia, Italy. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the preparation of zofenopril calcium salt. With a total of 2 patents to his name, Giachetti's work has had a meaningful impact on the industry.
Latest Patents
Giachetti's latest patents focus on the process for the preparation of zofenopril calcium salt. The first patent describes a method that involves the reaction of S(−)-3-benzoylthio-2-methylpropanoic acid chloride with cis-4-phenylthio-L-proline in water at a pH ranging from 9.0 to 9.5. This process allows for the recovery of zofenopril in its acidic form. The subsequent steps include salification of the acid zofenopril with a potassium salt in an alcoholic solution, followed by the conversion of the potassium salt to the calcium salt. This conversion is achieved by adding a zofenopril potassium salt aqueous solution to a CaCl aqueous solution at a temperature of 70-90°C, with simultaneous seeding to promote the precipitation of polymorph A.
Career Highlights
Throughout his career, Antonio Giachetti has worked with prominent companies in the pharmaceutical sector, including Menarini Ricerche S.p.A. and Menarini Ricerche S.p.A. His expertise in the field has allowed him to develop innovative processes that enhance the purity and efficacy of pharmaceutical compounds.
Collaborations
Giachetti has collaborated with esteemed colleagues such as Raffaello Giorgi and Carlo Mannucci. These partnerships have contributed to the advancement of research and development in pharmaceutical chemistry.
Conclusion
Antonio Giachetti is a distinguished inventor whose work in the preparation of zofenopril calcium salt has made a significant impact in the pharmaceutical industry. His innovative processes and collaborations highlight his commitment to advancing pharmaceutical chemistry.