Company Filing History:
Years Active: 2023
Title: Antonio D Di Stefano: Innovator in Myeloproliferative Neoplasms
Introduction
Antonio D Di Stefano is a notable inventor based in Rungis, France. He has made significant contributions to the field of medical research, particularly in understanding myeloproliferative neoplasms (MPN). His work has implications for diagnosing and treating patients with these conditions.
Latest Patents
Antonio D Di Stefano holds a patent for a "Prognostic marker for myeloproliferative neoplasms." This invention identifies a germline genomic alteration that accounts for familial MPN and myeloid malignancies. Specifically, he discovered a 700 kb germline duplication that predisposes patients to essential thrombocythemia (ET) with a high likelihood of progression to myelofibrosis (MF), secondary myelodysplastic syndromes (MDS), or acute myeloid leukemia (AML). The patent outlines a method for detecting predisposition to MPN and a prognostic method for assessing the risk of ET patients developing more severe conditions. Additionally, it describes a treatment method aimed at delaying the worsening of MPN by inhibiting the overexpressed genes ATG2B and GSKIP.
Career Highlights
Antonio D Di Stefano is affiliated with the Institut Gustave Roussy, a leading cancer research institution. His work has been pivotal in advancing the understanding of genetic factors in hematological malignancies. His research has the potential to improve patient outcomes through early detection and targeted therapies.
Collaborations
Antonio has collaborated with esteemed colleagues, including Christine Bellane-Chantelot and Isabelle Plo. These partnerships have enhanced the depth and impact of his research in the field of myeloproliferative neoplasms.
Conclusion
Antonio D Di Stefano's innovative work in identifying genetic markers for myeloproliferative neoplasms represents a significant advancement in medical research. His contributions are vital for improving diagnosis and treatment strategies for patients affected by these serious conditions.