Antonia Wallrapp

Title: Antonia Wallrapp: Innovator in Immunology

Introduction

Antonia Wallrapp is a prominent inventor based in Boston, MA, known for her significant contributions to the field of immunology. She has developed innovative methods and compositions that regulate innate lymphoid cell inflammatory responses. Her work has implications for understanding allergic inflammatory responses at mucosal surfaces.

Latest Patents

Antonia Wallrapp holds one patent titled "Methods and compositions for regulating innate lymphoid cell inflammatory responses." This patent details the computational and functional analysis that identified the neuropeptide receptor Nmur1 as selectively expressed on Type 2 innate lymphoid cells (ILC2s). The research highlights that while both IL-33 and IL-25 promote ILC activation in vivo, IL-33 induces robust ILC proliferation, whereas ILCs activated with IL-25 do not proliferate as robustly. The study further reveals that co-administration of IL-25 with neuromedin U (NMU) dramatically amplifies allergic lung inflammation and induces the proliferation and expansion of specific ILC2 subsets.

Career Highlights

Antonia has worked with prestigious organizations such as the Broad Institute, Inc. and the Massachusetts Institute of Technology. Her research has significantly advanced the understanding of neuro-immune crosstalk in allergic inflammatory responses, showcasing her expertise in the field.

Collaborations

Antonia has collaborated with notable colleagues, including Samantha J. Riesenfeld and Patrick R. Burkett. These collaborations have contributed to her innovative research and the development of her patent.

Conclusion

Antonia Wallrapp is a trailblazer in immunology, with her patent reflecting her dedication to advancing scientific knowledge. Her work continues to influence the understanding of immune responses and allergic conditions.