Company Filing History:
Years Active: 2003-2025
Title: Innovations in Cancer Treatment by Anthony N Van Den Pol
Introduction
Anthony N Van Den Pol is a prominent inventor based in Branford, CT (US). He has made significant contributions to the field of cancer treatment through his innovative research and patented technologies. With a total of 5 patents, his work focuses on the development of chimeric viruses for therapeutic applications.
Latest Patents
One of his latest patents involves methods for the treatment of cancer using a chikungunya-VSV chimeric virus. This invention provides chimeric viruses that have a vesicular stomatitis virus (VSV) background, where the VSV G protein is supplemented or replaced with alphavirus glycoproteins. The preferred alphavirus in this context is the Chikungunya virus. The patent outlines methods for using these chimeric viruses to treat various cancers, particularly brain cancers and their metastases. The chimeric viruses are designed to selectively infect and destroy cancer cells, such as glioblastoma and intracranial melanoma metastases, while exhibiting reduced toxicity to healthy cells compared to the parent VSV.
Another significant patent by Van Den Pol describes chimeric VSV virus compositions and methods for cancer treatment. This invention includes administering a pharmaceutical composition containing an effective amount of a chimeric VSV virus to a subject with cancer. The chimeric viruses are based on a VSV background, with the VSV G protein replaced by glycoproteins from other viruses, such as Lassa virus. This results in an oncolytic virus that is safe for use in the brain while retaining the ability to infect and destroy cancer cells, generating an immune response against them.
Career Highlights
Anthony N Van Den Pol has had a distinguished career, working at prestigious institutions such as Yale University and Leland Stanford Junior University. His research has significantly advanced the understanding and treatment of cancer, particularly through the innovative use of viral therapies.
Collaborations
Throughout his career, Van Den Pol has collaborated with notable colleagues, including Guido Wollmann and H Craig Heller. These collaborations have contributed to the development of his groundbreaking research and patents.
Conclusion
Anthony N Van Den Pol's innovative work in the field of cancer treatment through chimeric viruses represents a significant advancement in medical science. His contributions continue to pave the way for new therapeutic strategies in oncology.