Anthony Michael Slater

Title: Innovations by Inventor Anthony Michael Slater

Introduction

Anthony Michael Slater, based in Macclesfield, GB, is a prominent inventor known for his significant contributions to the fields of medicinal chemistry and biotechnology. He holds three patents that demonstrate his innovative approach to developing treatments that target complex medical conditions, particularly in the realm of anticoagulation and cancer therapy.

Latest Patents

Among Anthony's latest patents is his work on heterocyclic derivatives that inhibit factor Xa. This invention focuses on heterocyclic derivatives, or their pharmaceutically-acceptable salts, that possess valuable antithrombotic and anticoagulant properties. These compounds are designed for therapeutic use in both humans and animals. The patent also includes methods for preparing these heterocyclic derivatives, pharmaceutical compositions containing them, and their applications in manufacturing medicaments intended to produce an antithrombotic or anticoagulant effect.

Additionally, Slater has developed systems for Antibody Directed Enzyme Prodrug Therapy (ADEPT) to treat cancer. This innovation centers on mutated carboxypeptidase B (CPB) enzymes that are substantially non-immunogenic in humans. These enzyme conjugates have a targeting moiety, such as an antibody, that binds with tumor-associated antigens, thereby linking to a mutated form of a CPB enzyme. This innovative system enables the conversion of prodrugs into antineoplastic drugs, with the prodrug being minimally convertible into the drug by unmutated enzymes in humans. A preferred enzyme mutant in his work is the human pancreatic CPB featuring a Lys or Arg residue at position 253.

Career Highlights

Throughout his career, Anthony Michael Slater has worked with leading pharmaceutical companies, including Zeneca Limited and AstraZeneca AB. His work within these organizations has not only contributed to his patent portfolio but has also advanced research and development in medicinal therapies.

Collaborations

During his career, Slater has collaborated with notable coworkers such as John Frederick Hennam and David Charles Blakey. These partnerships have been instrumental in the development and refinement of his innovative therapies, facilitating impactful advancements in the medical field.

Conclusion

Anthony Michael Slater's innovative contributions have positioned him as a distinguished inventor in the healthcare sector. With his patents centered around life-saving medical advancements, his work continues to inspire further research and development in pharmaceuticals, benefiting both patients and the wider medical community.