This inventor holds 1 USPTO granted patent. Top assignee: University of Virginia Patent Foundation. Active years: 2017.
Company Filing History:
Years Active: 2017
Title: Innovations in Tissue Engineering by Anthony Awojoodu
Introduction
Anthony Awojoodu is an accomplished inventor based in Burtonsville, MD (US). He has made significant contributions to the field of tissue engineering and cell-based therapies. His innovative work focuses on strategies to enhance stem cell mobilization and recruitment, which has important implications for regenerative medicine.
Latest Patents
Anthony Awojoodu holds a patent titled "Compositions and methods for tissue engineering and cell based therapies." This patent discloses strategies to recruit and mobilize stem cells using S1P receptor selective agonists and antagonists, as well as regulators of chemokine receptors. In an in vivo ischemic model, S1P/S1P activation with FTY720 impeded inflammatory cell infiltration and recruited endothelial progenitor cells (EPCs), which have the potential to increase microvascular remodeling. The expression of S1P on marrow-derived cells was essential for this remodeling. Concurrent systemic S1P and CXCR4 antagonism mobilized hematopoietic stem cells (HSCs) capable of engrafting and repopulating blood cells. Pre-treatment of donor HSCs with FTY720 increased their homing toward SDF-1 and improved engraftment in marrow. FTY720-coated bone allografts, coupled with systemic administration of VPC01091, enhanced bone allograft integration and new bone formation in bone defects. MSCs pre-treated with FTY720 exhibited increased migration toward SDF-1, a CXCR4+ ligand. The results demonstrate that S1P plays a powerful role in pharmacological marrow-derived stem cell mobilization and recruitment.
Career Highlights
Anthony Awojoodu is associated with the University of Virginia Patent Foundation, where he continues to advance his research and innovations in the field of tissue engineering. His work has the potential to significantly impact medical treatments and improve patient outcomes.
Collaborations
Anthony has collaborated with notable colleagues, including Edward A Botchwey, III, and Mary J Laughlin. Their combined expertise contributes to the advancement of research in stem cell therapies and tissue engineering.
Conclusion
Anthony Awojoodu's innovative contributions to tissue engineering and cell-based therapies highlight the importance of stem cell mobilization in regenerative medicine. His work continues to pave the way for future advancements in this critical field.