Anthony A Molinero

Title: Innovations of Anthony A Molinero

Introduction

Anthony A Molinero is a notable inventor based in Christiansburg, VA (US). He has made significant contributions to the field of chemistry, particularly in the development of methods for converting natural products into valuable anticancer compounds. With a total of 2 patents, his work has implications for cancer treatment and pharmaceutical development.

Latest Patents

Molinero's latest patents focus on the conversion of cephalomannine to taxol, an important anticancer natural product. One method involves a simple process that includes dihydroxylation to produce cephalomannine-diols, followed by diol cleavage, benzoylation at the 2'-position, and reaction with a 1,2-diamine. This process allows for the separation of taxol from cephalomannine-diols using flash-chromatography after the dihydroxylation step. Additionally, if the benzoylation step is omitted, the process yields the free amine (N-debenzoyltaxol). By selecting different acylating reagents, taxol analogs with various N-acyl substituents can also be prepared. Another method described in his patents involves hydrogenation, benzoylation at the C-2'-position, protection of the C-7 position, and subsequent reactions that facilitate the conversion of cephalomannine to taxol without the need for separation of closely related compounds.

Career Highlights

Throughout his career, Molinero has worked with esteemed organizations such as Virginia Tech Intellectual Properties, Inc. and Virginia Polytechnic Institute and State University. His innovative approaches have contributed to advancements in the field of medicinal chemistry.

Collaborations

Molinero has collaborated with notable individuals in his field, including David G Kingston and A A Gunatilaka. These partnerships have likely enhanced the scope and impact of his research.

Conclusion

Anthony A Molinero's contributions to the field of chemistry, particularly in the development of methods for converting cephalomannine to taxol, highlight his innovative spirit and dedication to advancing cancer treatment. His work continues to influence the pharmaceutical industry and offers hope for improved therapeutic options.