Company Filing History:
2 out of 219 
2 out of 22 
1 out of 45 Years Active: 2020-2025
Title: Innovations by Annie De Groot
Introduction
Annie De Groot is a prominent inventor based in Providence, Rhode Island. She has made significant contributions to the field of therapeutic proteins, particularly in the development of recombinant coagulation factors. With a total of three patents to her name, her work has had a profound impact on the treatment of patients with Hemophilia A.
Latest Patents
One of her latest patents is focused on a de-immunized factor VIII molecule and pharmaceutical compositions comprising the same. This invention relates to recombinant coagulation factors and provides a recombinant Factor VIII (FVIII) protein with specific point mutations that reduce its immunogenicity while retaining coagulant activity. This innovation is particularly beneficial for patients with Hemophilia A, including those who have not previously been treated with FVIII products. It also offers a safe alternative for patients who have developed an immune response to FVIII, making it useful for immune-tolerance-induction therapy. Another notable patent involves peptides for inducing heterosubtypic influenza T cell responses. This invention provides methods for generating an anti-influenza immune response by identifying conserved T cell epitopes within the influenza virus.
Career Highlights
Annie De Groot has worked with esteemed institutions such as Saint Louis University and Epivax, Inc. Her research has been pivotal in advancing the understanding and treatment of various medical conditions through innovative therapeutic approaches.
Collaborations
She has collaborated with notable colleagues, including Daniel Hoft and Christopher S. Eickhoff, contributing to a rich exchange of ideas and advancements in her field.
Conclusion
Annie De Groot's innovative work in therapeutic proteins and her contributions to the medical field exemplify the impact of dedicated inventors on healthcare. Her patents not only advance scientific knowledge but also provide practical solutions for patients in need.