Saint Louis University

Epivax, Inc.

Biotest Ag

Annie De Groot

Daniel Hoft

William Martin

Jens Daufenbach

Steffen Kistner

Karina Winterling

Christopher S Eickhoff

Chris Eickhoff

Christopher Ungerer

The present invention relates to the field of therapeutic proteins, in particular, to recombinant coagulation factors. It provides a recombinant Factor VIII (FVIII) protein comprising specific point mutations at defined positions, which serve to reduce the immunogenicity of said FVIII protein, wherein the Factor VIII protein substantially retains its coagulant activity. It further provides nucleic acids encoding said de-immunized protein, cell lines and methods of recombinant preparation as well as pharmaceutical compositions comprising the recombinant FVIII of the invention, which are advantageous for use in treatment of patients with Hemophilia A, particularly those who have not yet been treated with a FVIII product. Additionally, it can be a safe alternative for previously treated patients and even for patients who have developed an immune-response to FVIII, e.g., for immune-tolerance-induction therapy (ITI/ITT) or rescue ITI. The invention also provides an assay for determining immunogenicity of a protein.

De-immunized factor VIII molecule and pharmaceutical compositions comprising the same

The present invention provides compositions and methods for generation of an anti-influenza immune response. In particular, conserved T cell epitopes within matrix protein and nucleoprotein components of influenza virus have been identified and further screened for those structures that will bind either or both of HLA I and II molecules. Methods for vaccinating subjects with formulations of such peptides for the treatment or prevention of influenza infection also are described.

Peptides for inducing heterosubtypic influenza T cell responses

The present disclosure relates to vaccine formulations and their use in treating and preventing Chagas Disease.

Peptides for inducing Chagas disease responses

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Providence, RI, United States of America

Annie De Groot