This inventor holds 2 USPTO granted patents and 1 published patent application. Top assignee: Johns Hopkins University. Active years: 2020-2021.
Company Filing History:
Years Active: 2020-2021
Title: Innovations in Cancer Therapy by Inventor Anne Le
Introduction
Anne Le is a prominent inventor based in Baltimore, MD (US), known for her groundbreaking work in cancer therapy. With a focus on enhancing the efficacy of glutaminase inhibitors, she has made significant contributions to the field of oncology. Anne holds 2 patents that reflect her innovative approach to addressing the challenges associated with cancer treatment.
Latest Patents
Anne Le's latest patents include the discovery of glutaminase inhibitors and the development of nanoparticle-enhanced delivery systems for cancer therapy. Current glutaminase inhibitors often suffer from poor solubility, metabolic instability, and the need for high doses, which can diminish their therapeutic effectiveness. By formulating these inhibitors into nanoparticles, Anne has created a method for safe and effective delivery, particularly for pancreatic cancer and other cancers that are dependent on glutamine. Studies indicate that the nanoparticle delivery of BPTES, compared to its standalone use, significantly improves tumor drug exposure and overall efficacy. The use of sub-100 nm nanoparticles allows for higher concentrations of GLS inhibitors to be administered, as these nanoparticles encapsulate the drug in a soluble form. This targeted delivery takes advantage of the enhanced permeability and retention (EPR) effect, resulting in sustained drug levels above the IC50 within tumors for extended periods. This innovative approach provides a marked improvement in efficacy compared to unencapsulated drugs.
Career Highlights
Anne Le is affiliated with The Johns Hopkins University, where she continues to advance her research in cancer therapy. Her work is characterized by a commitment to improving treatment outcomes for patients suffering from various forms of cancer.
Collaborations
Some of Anne's notable coworkers include Barbara S Slusher and Takashi Tsukamoto, who contribute to her research efforts and innovations in the field.
Conclusion
Anne Le's contributions to cancer therapy through her innovative patents and research at The Johns Hopkins University highlight her role as a leading inventor in the medical field. Her work promises to enhance treatment options and improve patient outcomes in oncology.