Location History:
- Milan, IT (1992)
- Legnano, IT (1988 - 2022)
Company Filing History:
5 out of 5 
3 out of 35 
2 out of 2,483 
Years Active: 1988-2022
Title: **Annamaria Naggi: Innovator in Glycosaminoglycan Derivatives**
Introduction
Annamaria Naggi, located in Legnano, Italy, is a prominent inventor in the field of medicinal chemistry, particularly known for her impactful contributions to the development of glycosaminoglycan derivatives. With an impressive portfolio that includes 19 patents, her research focuses on innovative approaches to drug development.
Latest Patents
Naggi's latest patents detail her work on carboxylated derivatives of glycosaminoglycans, showcasing their use as drugs with particular emphasis on their heparanase inhibitory and antitumor activities. These derivatives contain carboxylate groups in specific positions on the glycosaminoglycan residues. The innovative process of generating these derivatives involves starting from natural or synthetic glycosaminoglycans, such as heparin or low molecular weight heparin, which may be 2-O- and 2-N-desulfated through a two-step oxidation process. The initial oxidation converts adjacent dials and hydroxyl or amino groups into aldehydes, followed by a second oxidation that transforms these aldehydes into carboxylate groups. This meticulous process underscores her dedication to advancing therapeutic strategies through chemical innovation.
Career Highlights
Annamaria has worked with respected organizations such as Novahealth Biosystems, LLC and Crinos Industria Farmacobiologica S.p.a. Her positions in these companies reflect her expertise and commitment to pharmaceutical advancements. Throughout her career, she has been at the forefront of research aimed at developing new medicinal compounds that can greatly enhance patient care.
Collaborations
During her career, Naggi has collaborated with notable figures in her field, including Giangiacomo Torri and Benito Casu. These collaborations have allowed her to leverage diverse expertise and insights, fostering advancements in her research and contributing to her successful patent portfolio.
Conclusion
Annamaria Naggi's contributions to the field of glycosaminoglycan derivatives exemplify the significant role that innovative research plays in the medical landscape. Her 19 patents illustrate her dedication to advancing therapeutic options, and her collaborations with distinguished colleagues further enhance her impact on pharmaceutical science. Her pioneering work is poised to influence drug development and therapeutic strategies for years to come.