Company Filing History:
Years Active: 2007
Title: The Innovative Contributions of Anna T Riegel
Introduction
Anna T Riegel is a prominent inventor based in Washington, DC, known for her significant contributions to the field of breast cancer research. With a focus on the AIB1 protein, her work has implications for the diagnosis and treatment of breast cancer. She holds one patent that highlights her innovative approach to understanding cancer biology.
Latest Patents
Anna T Riegel's patent, titled "Coactivators in the diagnosis and treatment of breast cancer," relates to the AIB1 protein as a coactivator that enhances the transcriptional activity of nuclear hormone receptors. This invention is particularly relevant as the AIB1 gene is amplified in a subset of human breast cancers. One splice variant of AIB1, known as Δ3-AIB1, transcribes an mRNA that lacks the exon 3 sequence. The Δ3-AIB1 mRNA encodes a 130 kDa protein that is detected in MCF-7 breast cancer cells at levels of 5-10% of the full-length protein. In contrast, non-transformed mammary epithelium lines show significantly lower levels of the Δ3-AIB1 protein compared to the full-length AIB1. The abundance of Δ3-AIB1 mRNA is increased in human breast cancer specimens relative to normal breast tissue. Functional reporter gene assays have demonstrated that Δ3-AIB1 promotes transcription mediated by estrogen or progesterone receptors more effectively than the full-length protein. Additionally, the Δ3-AIB1 isoform is more effective than AIB1 in promoting transcription induced by epidermal growth factor. This suggests that the overexpression of Δ3-AIB1 plays a crucial role in sensitizing breast tumor cells to hormone or growth factor stimulation.
Career Highlights
Anna T Riegel is affiliated with Georgetown University, where she continues her research and innovation in cancer biology. Her work has garnered attention for its potential to improve breast cancer diagnosis and treatment strategies.
Collaborations
Anna has collaborated with notable colleagues, including Ronald Reiter and Anton Wellstein, who have contributed to her research endeavors.
Conclusion
Anna T Riegel's innovative work in the field of breast cancer research exemplifies the impact of scientific inquiry on medical advancements. Her patent on the AIB1 protein underscores the importance of understanding molecular mechanisms in cancer treatment.