Anna M Tempcyzk-Russell

Title: Innovations of Anna M Tempcyzk-Russell

Introduction

Anna M Tempcyzk-Russell is a prominent inventor based in San Diego, CA. She has made significant contributions to the field of biochemistry, particularly in the study of vascular endothelial growth factor receptor-2 (VEGFR2/KDR). With a total of 5 patents to her name, her work has implications for therapeutic advancements in various disease conditions.

Latest Patents

One of her latest patents involves modifications of the VEGF receptor-2 protein and methods of use. This patent describes a 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of VEGFR2/KDR, which is a key enzyme in angiogenesis. The protein construct features a modified catalytic linker and demonstrates comparable in vitro kinase activity to constructs containing the entire KID. Importantly, this construct allows for complete crystallization of the protein, enabling characterization through X-ray crystallography. The invention also discloses the use of the X-ray crystallographic data for identifying and constructing potential therapeutic compounds for treating various diseases.

Career Highlights

Anna is currently employed at Agouron Pharmaceuticals, Inc., where she continues her research and development efforts. Her work has been instrumental in advancing the understanding of protein structures and their applications in medicine.

Collaborations

Some of her notable coworkers include Chen-Chen Kan and Michele Ann McTigue, with whom she has collaborated on various projects.

Conclusion

Anna M Tempcyzk-Russell's innovative work in the field of biochemistry and her contributions to the understanding of VEGFR2/KDR highlight her importance as an inventor. Her patents pave the way for potential therapeutic advancements that could benefit many.