Ann B Begovich

Title: Ann B Begovich: Innovator in HLA DP Typing

Introduction

Ann B Begovich is a notable inventor based in El Cerrito, California. She has made significant contributions to the field of genetics, particularly in the area of HLA DP typing. With a total of 2 patents, her work has implications for various medical and forensic applications.

Latest Patents

One of her latest patents is a method for HLA DP typing. This innovative process determines the genotype of an individual concerning the alleles at the HLA DP locus. It involves obtaining a sample of nucleic acid from the individual and hybridizing the nucleic acids with a panel of probes specific for variant segments of the DPalpha and DPbeta genes. The method is highly discriminating and informative, surpassing traditional cellular, RFLP, or serological methods. It can also be performed on amplified nucleic acid produced by the polymerase chain reaction using specific primers. HLA DP DNA typing methods are crucial in preventing graft rejection, determining susceptibility to autoimmune diseases, providing forensic evidence, and conducting paternity testing.

Career Highlights

Ann B Begovich is associated with Hoffmann-La Roche Inc., where she continues to advance her research and innovations. Her work has garnered attention for its potential to improve medical outcomes and enhance genetic understanding.

Collaborations

She has collaborated with notable colleagues such as Henry A Erlich and Glenn T Horn, contributing to the advancement of genetic research and applications.

Conclusion

Ann B Begovich's contributions to HLA DP typing represent a significant advancement in genetic research. Her innovative methods have the potential to impact various fields, including medicine and forensics.