Company Filing History:
Years Active: 2000-2003
Title: Anke Klippel: Innovator in PI 3-Kinase Research
Introduction
Anke Klippel is a prominent inventor based in San Francisco, CA (US). She has made significant contributions to the field of biochemistry, particularly in the area of phosphoinositide 3-kinase (PI 3-kinase) research. With a total of 3 patents, her work has implications for therapeutic and research applications.
Latest Patents
Anke Klippel's latest patents include innovative methods and constructs related to PI 3-kinase. One of her notable inventions is the development of polynucleotide constructs encoding growth factor-independent catalytically active membrane-targeted PI 3-kinase mutants. These constructs are useful for therapeutic and research purposes. Additionally, she has described methods for screening inhibitors of PI 3-kinase, producing 3′ phosphorylated inositol phospholipids, reducing cell death after trauma, and overcoming insulin resistance. Another significant patent involves a method for producing a constitutively active PI 3-kinase, which functions independently of growth factor stimulation. This invention provides expression vectors and methods for generating phosphoinositides and identifying cellular target proteins.
Career Highlights
Anke Klippel has worked with esteemed organizations such as the University of California and Chiron Corporation. Her research has been pivotal in advancing the understanding of PI 3-kinase and its role in various diseases, particularly proliferative diseases.
Collaborations
Throughout her career, Anke has collaborated with notable colleagues, including Lewis T. Williams and W. Michael Kavanaugh. These collaborations have further enriched her research and contributed to her innovative work in the field.
Conclusion
Anke Klippel's contributions to PI 3-kinase research highlight her role as a leading inventor in biochemistry. Her patents and collaborative efforts continue to influence therapeutic strategies and research methodologies.