Company Filing History:
Years Active: 2014
Title: Innovations of Angela L Perkins-Harki
Introduction
Angela L Perkins-Harki is a notable inventor based in Minneapolis, MN (US). She has made significant contributions to the field of cancer research through her innovative work. Her expertise lies in developing compositions that aid in understanding cellular functions and treatment methodologies.
Latest Patents
Angela holds a patent for "Multi-valent poly-Ubl chain inhibitors and methods of use." This composition is designed to develop a reagent for investigating Ubl-modifications in cellular functions and in the treatment of cancer. The composition comprises gold nanoparticle (AuNP)-ligand conjugates that include at least two components: gold nanoparticles (AuNPs) and modified ubiquitin- or ubiquitin-like interacting motif (UIM or ULIM) mimetics. In one embodiment, the modified ULM mimetic is a modified SUMO interaction motif (SIM) mimetic. The compound inhibits ubiquitin- or ubiquitin-like protein (Ubl)-mediated protein-protein interactions and sensitizes cells to ionizing radiation. The modified UIM and ULIM mimetics may be conjugated to the AuNP such that each AuNP is conjugated to a plurality of modified UIM or ULIM mimetics. The modified ULIM mimetics may be conjugated to the AuNP via a thiol group.
Career Highlights
Angela is currently associated with City of Hope, where she continues her research and development efforts. Her work has been instrumental in advancing the understanding of cancer treatment options.
Collaborations
Angela has collaborated with notable colleagues such as Yuan Chen and David A Horne, contributing to a dynamic research environment.
Conclusion
Angela L Perkins-Harki is a pioneering inventor whose work in cancer research exemplifies innovation and dedication. Her contributions through her patent and collaborations highlight her commitment to advancing medical science.