The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2014
Filed:
Feb. 21, 2012
Yuan Chen, Arcadia, CA (US);
David Horne, Duarte, CA (US);
Yi-jia LI, Duarte, CA (US);
Yuelong MA, Duarte, CA (US);
Angela L. Perkins-harki, Minneapolis, MN (US);
Yang Su, Beijing, CN;
Yuan Chen, Arcadia, CA (US);
David Horne, Duarte, CA (US);
Yi-Jia Li, Duarte, CA (US);
Yuelong Ma, Duarte, CA (US);
Angela L. Perkins-Harki, Minneapolis, MN (US);
Yang Su, Beijing, CN;
City of Hope, Duarte, CA (US);
Abstract
A composition used to develop a reagent for investigating Ubl-modifications in cellular functions and in the treatment of cancer is provided. The composition comprises gold nanoparticle (AuNP)-ligand conjugates that include at least two components: gold nanoparticles (AuNPs) and modified ubiquitin- or ubiquitin-like interacting motif (UIM or ULIM) mimetics. In one embodiment, the modified ULM mimetic is a modified SUMO interaction motif (SIM) mimetic. According to the embodiments described herein, the compound inhibits ubiquitin- or ubiquitin-like protein (Ubl)-mediated protein-protein interactions and sensitizes cells to ionizing radiation. The modified UIM and ULIM mimetics may be conjugated to the AuNP such that each AuNP is conjugated to a plurality of modified UIM or ULIM mimetics. The modified ULIM mimetics may be conjugated to the AuNP via a thiol group.