Company Filing History:
Years Active: 1997
Title: Angel Nikolov Konakchiev: Innovator in Pharmaceutical Chemistry
Introduction
Angel Nikolov Konakchiev is a notable inventor based in Sofia, Bulgaria. He has made significant contributions to the field of pharmaceutical chemistry, particularly through his innovative processes in drug preparation. His work has implications for the development of effective treatments.
Latest Patents
Konakchiev holds a patent for a process for the preparation of dihydroartemisinin hemisuccinate. This process involves the acylation of dihydroartemisinin with 1.0 to 1.3 molar equivalents of succinic anhydride. It is conducted in the presence of 0.5 to 1.5 molar equivalents of tri(C.sub.1 -C.sub.3 -alkyl)amine in a low-boiling, neutral, water-miscible, inert organic solvent or solvent mixture. The product is isolated at pH 5-8 and is obtained directly in crystalline form and high yield. This innovation is crucial for enhancing the efficacy of treatments derived from dihydroartemisinin.
Career Highlights
Konakchiev is currently associated with Mepha AG, where he continues to advance his research and development efforts. His work at Mepha AG has allowed him to focus on innovative pharmaceutical solutions that can improve patient outcomes.
Collaborations
Some of his notable coworkers include Iliya Vassilev Ognyanov and Ralph Hanni. Their collaborative efforts contribute to the ongoing advancements in pharmaceutical research and development.
Conclusion
Angel Nikolov Konakchiev is a distinguished inventor whose work in pharmaceutical chemistry has led to significant innovations. His patent for the preparation of dihydroartemisinin hemisuccinate exemplifies his commitment to improving drug efficacy. His contributions continue to impact the field positively.