Andrew Hayhurst

Title: Innovations of Andrew Hayhurst

Introduction

Andrew Hayhurst is an accomplished inventor based in Austin, TX. He has made significant contributions to the field of binding proteins, with a focus on developing innovative techniques for isolating these proteins. His work has led to the filing of two patents, showcasing his expertise and dedication to advancing scientific knowledge.

Latest Patents

Hayhurst's latest patents revolve around the isolation of binding proteins with high affinity to ligands. This invention addresses the limitations of previous methods by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides through 'display-less' library screening. In this technique, libraries of candidate binding proteins, such as antibody sequences, are expressed in soluble form in the periplasmic space of gram-negative bacteria. These proteins are then mixed with a labeled ligand. Clones expressing recombinant polypeptides with affinity for the ligand show an increased concentration of the labeled ligand bound to the binding protein, allowing for the isolation of these cells from the rest of the library. When fluorescent labeling of the target ligand is utilized, cells can be isolated using fluorescence-activated cell sorting (FACS). This approach is more efficient than prior art methods and circumvents issues associated with the surface expression of ligand fusion proteins used in phage display.

Career Highlights

Andrew Hayhurst has built a notable career at the University of Texas System, where he continues to innovate and contribute to the scientific community. His work has not only advanced the understanding of binding proteins but has also paved the way for new applications in various fields.

Collaborations

Hayhurst has collaborated with esteemed colleagues, including Gang Chen and Jeffrey G Thomas, further enhancing the impact of his research and inventions.

Conclusion

In summary, Andrew Hayhurst is a prominent inventor whose work on binding proteins has led to significant advancements in the field. His innovative patents and collaborations reflect his commitment to scientific progress and the development of new technologies.