Andrew Fales

Title: Andrew Fales: Pioneering Innovations in Nano-Plasmonics

Introduction

Andrew Fales is a prominent inventor based in Durham, North Carolina, known for his significant contributions to the field of nano-plasmonics. With a total of six patents to his name, his work focuses on developing advanced molecular probes and methodologies that enable sensitive detection of biomolecules, which have critical applications in medical diagnostics and treatments.

Latest Patents

Among Andrew's latest innovations are two notable patents: the "Nano-plasmonic Molecular Probes and Methods of Use" and "Plasmonics-active Metal Nanostar Compositions and Methods of Use." The first patent outlines the creation of plasmonics-active nanoprobes designed for the detection of various target biomolecules such as nucleic acids, proteins, and small molecules. These nanoprobes can detect RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). They enable sensitive diagnostic methods for diseases, including cancer, and allow for multiplexing, enabling simultaneous detection of multiple targets within a single sample. Furthermore, these nanoprobes exhibit a visible color change for detection purposes and can be applied in vivo for the targeted treatment of undesirable cells.

The second patent introduces plasmonics-active metal nanostars capable of treating and detecting cells in subjects. This innovation incorporates a photo-activated drug, activated through the nanostar’s photo-response to electromagnetic stimulation, a thermally-activated drug reacting to thermal stimulation, and direct or indirect cell death resulting from the nanostar’s thermal response. The uptake of these nanostars can enhance imaging contrast, aiding in the detection of undesirable cells.

Career Highlights

Andrew Fales's career is highlighted by his affiliation with Duke University, where he conducts groundbreaking research in the field of biosensing and nano-therapeutics. His dedication to advancing technology within his field has not only earned him multiple patents but also recognition from his peers and institutions.

Collaborations

Andrew has collaborated with esteemed colleagues such as Tuan Vo-Dinh and Hsiangkuo Yuan, further enriching his research and contributing to the innovative developments in biosensing technologies. These collaborations have been instrumental in pushing the boundaries of what is possible within nano-plasmonic applications.

Conclusion

In summary, Andrew Fales stands out as an influential inventor whose work in nano-plasmonics is paving the way for revolutionary advancements in molecular detection and treatment methodologies. His contributions are not only significant for scientific research but also hold promise for transformative impacts on medical diagnostics and therapeutic strategies.