Middletown, CT, United States of America

Andrew D Williams


Average Co-Inventor Count = 5.1

ph-index = 3

Forward Citations = 22(Granted Patents)


Company Filing History:


Years Active: 1994-1996

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3 patents (USPTO):Explore Patents

Title: The Innovative Contributions of Andrew D. Williams

Introduction

Andrew D. Williams is a notable inventor based in Middletown, CT (US). He has made significant contributions to the field of pharmaceuticals, particularly in the development of antimigraine agents. With a total of 3 patents to his name, Williams has demonstrated a commitment to advancing medical science through innovative processes.

Latest Patents

One of his latest patents is a process for large-scale production of indolyl alkyl pyrimidinyl. This improved, novel convergent process is suitable for the large-scale preparation of the antimigraine agent 4-(5-methoxy-4-pyrimidinyl)-1-[3-[5-[[(methylamino)sulfonyl]methyl]-1H-indol-3-yl]propyl]piperazine (BMS 180048) and its close analogs. The process enhances efficiencies in handling, purification, and product yield. It involves a novel heteroannulation reaction that provides the indole ring moiety and propylpiperazinyl-pyrimidine backbone in a single step. Another significant patent involves a series of novel alkoxypyridin-4-yl and alkoxypyrimidin-4-yl derivatives of indol-3-ylalkylpiperazines, which are intended to be useful agents for alleviating vascular headaches due to their potent affinity and agonist activity at 5-HT1D binding sites.

Career Highlights

Andrew D. Williams is currently employed at Bristol-Myers Squibb Company, where he continues to innovate in the pharmaceutical industry. His work focuses on developing effective treatments for migraine sufferers, showcasing his dedication to improving patient outcomes through scientific research.

Collaborations

Williams has collaborated with notable coworkers such as David W. Smith and Joseph P. Yevich. These partnerships have likely contributed to the success of his innovative projects and patents.

Conclusion

In summary, Andrew D. Williams is a distinguished inventor whose work in the pharmaceutical field has led to significant advancements in antimigraine treatments. His innovative processes and collaborations highlight his commitment to improving healthcare through science.

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